Objective To explore the application effect of four-dimensional interactive teaching based on the BOPPPS model in emergency nursing practical training courses, and to provide evidence for effectively enhancing students′ competence in emergency nursing roles. Methods Using the cluster sampling, 261 undergraduate nursing students from the 2020 grade were selected as the control group, while 258 students from the 2021 grade were assigned to the observation group, respectively. The study was conducted in the emergency nursing practical training course offered in the sixth semester.The control group received the traditional practical training teaching model,and the observation group was subjected to the four-dimensional interactive teaching model empowered by the BOPPPS framework. The two groups were compared in terms of emergency nursing assessment scores, academic self-efficacy, critical thinking ability, and core emergency nursing competencies.Results The observation group showed significantly higher scores in theoretical and practical assessments of emergency nursing, overall scores, academic self-efficacy, critical thinking ability, and core emergency nursing competencies compared with the control group (all P<0.05). Conclusion The introduction of four-dimensional interactive teaching based on the BOPPPS model in emergency nursing practical training courses promotes the coordinated development of students′ professional knowledge acquisition and comprehensive quality, providing a practical and feasible path for the reform of emergency nursing practical training courses.