Objective To explore the implementation effect of an integrated inpatient-day care and full-course management program under the Diagnosis Related Groups (DRG) payment policy, and to provide a reference for the management of hematology wards and oncology-related wards. Methods Patients who attended inpatient and day care services from January to December, 2023, were assigned to the control group and received routine nursing care. Patients who attended inpatient and day care services from January to December, 2024, were assigned to the observation group and subjected to a nurse-led integrated inpatient-day care and full-course management program. The inpatient and day-care treatment status and DRG payment-related indicators were compared between the two groups. Results Compared with the control group, the number of inpatient cases in the observation group increased by 12.92%, and the average length of stay was significantly shortened (P<0.05); the number of day care visits in the observation group increased by 71.04% compared with the control group; the incidence of overspending at discharge in the observation group was significantly lower than that in the control group (P<0.05), and the amount of overspending decreased by 57.82% compared with the control group. Conclusion The nurse-led integrated inpatient-day care and full-course management program, through process optimization and reasonable dynamic post settings, achieves a smooth transition and full-course management of hematological oncology patients from inpatient treatment to day care. It meets the diagnosis and treatment needs of patients, improves the efficiency and standardization of diagnosis and treatment, eases the economic burden on patients, and reflects the economic effectiveness of nurses.