Objective To develop a family collaborative care program for patients with severe acute pancreatitis during the Emergency Intensive Care Unit (EICU) transitional period based on the Secure-Encourage-Collaborate Framework, and to verify its application effect, so as to provide reference for clinical nursing practice.Methods A total of 120 pairs of severe acute pancreatitis patients planned to be transferred from the EICU to the general ward and their family members were equally divided into the control group and the observation group according to the hospitalization time. The control group received routine transitional care, while the observation group was subjected to a structured family collaborative care program based on the Secure-Encourage-Collaborate Framework on the basis of routine care. The intervention period spanned from 24 hours before the patient′s transfer out of the EICU to 5 days after transfer. The family caregivers′ caregiving ability, anxiety, depression, and satisfaction with participation in medical decision-making were compared between the two groups. Results After the intervention, the scores of family caregivers′ caregiving ability, anxiety, depression, and satisfaction with participation in medical decision-making in the observation group were significantly better than those in the control group (all P<0.05). Conclusion The family collaborative care program based on the Secure-Encourage-Collaborate Framework for the EICU transitional period can effectively alleviate the anxiety and depression of family members of patients with severe acute pancreatitis, and improve their caregiving ability and satisfaction with participation in medical decision-making.