Objective To investigate the current status of digital competence among clinical nurses and analyze its influencing factors, and to provide a reference for nursing managers to develop relevant management measures to improve nurses′ digital competence. Methods By using convenience sampling method, 1,120 clinical nurses were selected as research subjects from December 2024 to February 2025. A general information questionnaire, the Digital Competence Questionnaire, the Innovative Self-efficacy Scale and the Perceived Organizational Support Scale were used for questionnaire survey. Univariate analysis, Pearson correlation analysis and multiple linear regression analysis were used to explore the influencing factors of digital competence of clinical nurses.Results A total of 1,084 clinical nurses completed the survey, with a total score of digital competence of (48.47±8.01). Multiple linear regression analysis showed that gender, whether receiving relevant information technology training, innovative self-efficacy and perceived organizational support were the influencing factors of digital competence of clinical nurses (all P<0.05)，which accounted for 43.6% of the total variance. Conclusion The digital competence of clinical nurses is at a medium-upper level. Nursing managers should strengthen information technology training for nurses, especially the cultivation and support of innovative self-efficacy, provide them with more learning opportunities and practice platforms, and simultaneously strengthen organizational support, so as to further improve the digital competence of clinical nurses.