Objective To explore the application effect of a precise Kinesio taping treatment regimen guided by fascial chains in patients with head and facial edema after tongue cancer surgery. Methods A total of 98 patients with head and facial edema after tongue cancer surgery were divided into an intervention group and a control group using a random number table, with 49 cases in each group. The control group received routine nursing care for postoperative head and facial edema after tongue cancer, while the intervention group additionally received fascial chain-oriented precise Kinesio taping treatment. The improvement of head and facial edema, pain, and maximum mouth opening were compared between the two groups on the 1st, 3rd, and 7th days after surgery, and anxiety levels on the 7th postoperative day and length of hospital stay. Results Forty-six patients in both the intervention group and the control group completed the study. Regarding the comparison of postoperative head and facial edema degree, pain scores, and maximum mouth opening, there were statistically significant differences in intervention effects, time effects, and interaction effects (all P<0.05). The anxiety score of the intervention group on the 7th postoperative day was significantly lower than that of the control group, and the length of hospital stay was significantly shorter than that of the control group (all P<0.05). Conclusion Precise Kinesio taping guided by fascial chains is a safe and effective rehabilitation method that can effectively alleviate head and facial edema in patients after tongue cancer surgery and improve rehabilitation efficiency.