Objective To develop a home-based vascular rehabilitation nursing program for patients after interventional therapy for lower extremity deep vein thrombosis (DVT) and to evaluate its application effects. Methods A total of 96 patients with DVT were selected by convenience sampling.Patients enrolled from January to June 2024 served as the control group (n=48) and received the routine discharge guidance and follow-up.Patients enrolled from July to December 2024 were assigned to the intervention group (n=48), for whom a home-based vascular rehabilitation nursing program based on Integrated Theoryof Health Behavior Change (ITHBC) theory was constructed and implemented on the basis of the control group′s regimen.Knowledge, attitude, and practice (KAP) related to DVT, self-management, exercise self-efficacy, and medication adherence scores were compared between the two groups at 1, 3, and 6 months after discharge.The incidence of complications within 6 months was also recorded. Results Ultimately, 47 patients in the control group and 45 in the intervention group completed the study.The intervention group demonstrated significantly higher scores in KAP, self-management, exercise self-efficacy, and medication adherence than the control group at 1, 3, and 6 months after discharge. The intergroup, time and interaction effects differed significantly between the two groups (all P＜0.05).The total incidence of complications in the intervention group within 6 months after discharge was significantly lower than that in the control group (P＜0.05). Conclusion The implementation of the home-based vascular rehabilitation nursing program based on the ITHBC theory can effectively enhance disease knowledge, self-management ability, exercise self-efficacy, and medication adherence in patients after interventional therapy for lower extremity DVT, reduce the incidence of complications, and promote home rehabilitation.