Objective To summarize the perioperative nursing experience of patients with Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) undergoing ocular surface reconstruction surgery.Methods A total of 18 patients (19 eyes) with SJS/TEN underwent ocular surface reconstruction surgery.Preoperatively, we conducted comprehensive patient preparation through systematic safety education, psychological support, and thorough diagnotic tests. Postoperatively, our nursing care strategies encompassed meticulous oral management, specialized ocular care with vigilant complication monitoring, and precise implementation of pharmacological interventions.Results The 18 patients were operated smoothly, recovered well and discharged smoothly. At the 2-week follow-up after operation, all patients′ ocular surface epithelium healed, and the oral and labial mucosa at the ocular surface transplantation site survived well. During the follow-up period (the shortest one month, the longest 60 months), there were no complications such as graft shedding, bleeding, infection, etc. The visual acuity of all patients was steady or improved compared with that before operation, and the symptoms of eye irritation were obviously improved. Among them, the ocular surface of 18 eyes was stable, the symptom of dry eye was obviously relieved, the symblepharon was completely improved, and only one eye had a slight recurrence of symblepharon.Conclusion It is very important to strengthen perioperative nursing care of patients with SJS/TEN undergoing ocular surface reconstruction surgery and pay attention to the observation and nursing of postoperative complications.