We summarize the nursing experience for 115 patients with refractory or relapsed B cell non-Hodgkin lymphoma who underwent autologous hematopoietic stem cell transplantation (auto HSCT) conditioned with either BEAM or BEAMF followed by sequential CD19/22 chimeric antigen receptor T cell (CAR-T) therapy. In both the BEAM and BEAMF groups, the median time to neutrophil engraftment was 14 days and the median time to platelet engraftment was 15 days. All patients experienced grade 3-4 cytopenias attributable to the myeloablative conditioning regimens. The primary toxicities observed were oral mucositis, hypotension, abnormal liver function, and fever. Key nursing considerations included awareness of cumulative toxicities from sequential treatments, anticipation of risks specifically associated with the BEAMF conditioning regimen, and rigorous implementation of targeted nursing interventions to ensure treatment safety.