Objective To develop and evaluate the usability of the HIV peer support precision matching platform and to promote the health management of people living with HIV/AIDS. Methods A multidisciplinary research and development team was built to develop the platform based on the conceptual framework of HIV-related social support formed in a previous study. A mixed-methods approach was employed to evaluate the platform′s usability. Qualitative research utilized descriptive qualitative methods, conducting semi-structured interviews with six HIV/AIDS patients and analyzing data through content analysis. Quantitative research adopted a cross-sectional study design, collecting data from 130 users via the Chinese version of the System Usability Questionnaire. Results The platform comprises 10 core functional modules, including peer volunteer precision matching, drug interaction queries, and health management, etc. Respondents in the qualitative part of the study generally rated the platform′s functional effectiveness, operational efficiency and user management highly, and also put forward optimization suggestions such as merging similar functions and adding incentive mechanisms; in the quantitative part of the study, the median total score for the system usability questionnaire was 97.5 points (P25=77.5, P75=100), with 83.08% of users rating the platform′s usability highly. Conclusion The development of the HIV peer support precision matching platform is scientifically sound. Users perceive it as having good usability and it can be applied to the health management of people living with HIV. Further verification of the platform′s intervention effect is required in the future.