Objective To understand the current status of psychological crisis in cancer patients, and to analyze its influencing factors, so as to provide a reference for the clinical implementation of psychological crisis intervention for cancer patients. Methods A convenience sampling method was employed to select 239 cancer patients from September 2024 to March 2025, then they were surveyed by using a general information questionnaire, the Triage Assessment Form (TAF), the Herth Hope Index (HHI), the Perceived Social Support Scale (PSSS), the Self-perceived Burden Scale (SPBS), and the Mishel Uncertainty in Illness Scale for Adults (MUIS-A).Univariate and multivariate analysis were applied to explore the influencing factors of psychological crisis in cancer patients. Results The participants′ psychological crisis score was (13.02±4.37), and the incidence of psychological crisis was 53.97%.Multivariate linear regression analysis showed that, diagnosis time, presence of metastasis, the score of PSSS and HHI were the influencing factors of psychological crisis (all P＜0.05), which explained 45.6% of the total variation. Conclusion Psychological crisis in cancer patients is at a moderate level.Medical staff should focus on cancer patients with a diagnosis time of ＜3 months, presence of metastasis, low level of perceived social support and hope, accurately assess their psychological crisis level, and implement targeted psychological crisis intervention in time.