Objective To explore the latent profile characteristics and the influencing factors of cancer-related fatigue among hospita-lized cancer patients, so as to provide a reference for implementing targeted clinical interventions. Methods A convenience sample of 1,000 hospitalized cancer patients was selected, then they were investigated by using the Chinese version of the Brief Fatigue Inventory (BFI-C), the Barthel Index of Activities of Daily Living, the Numerical Rating Scale (NRS), the Generalized Anxiety Di-sorder-7 (GAD-7), the Patient Health Questionnaire-9 (PHQ-9), and the Nutritional Risk Screening 2002 (NRS 2002).Latent profile analysis was employed to identify latent categories of cancer-related fatigue, and univariate analysis and logistic regression analysis were conducted to explore the influencing factors. Results Cancer-related fatigue in hospitalized cancer patients was classified into three latent profiles:low fatigue-low comorbid symptoms group (56.1%), moderate fatigue-decreased work capacity group (33.5%), and severe fatigue-low self-care capability group (10.4%).Compared with the low fatigue-low comorbid symptoms group, those patients with caregivers, undergoing radiotherapy or chemotherapy, suffering from anemia, nutritional risk, sleep disturbance, pain, depression, or poor self-care ability were prone to be classified into the moderate fatigue-decreased work capacity group or/and severe fatigue-low self-care ability group (all P＜0.05). Conclusion Cancer-related fatigue in hospitalized cancer patients exhibits significant heterogeneity.Medical staff should routinely assess patients′ fatigue, pay close attention to their self-care ability, treatment modalities, nutritional status, and concomitant symptoms, so as to identify high-risk population, provide early nursing interventions, and reduce patients′ fatigue.