Objective To investigate and analyze the current status and influencing factors of confidence professional behavior among PICC specialized nurses, and to provide a reference for developing targeted interventions to enhance the confidence professional behavior of PICC specialized nurses. Methods A total of 382 PICC specialized nurses from 15 tertiary hospitals in Xi′an were selected using convenience sampling method, then they were investigated by utilizing a general information questionnaire, the Self-assessment Scale of Confidence Professional Behavior for PICC specialized nurses, the Essentials of Magnetism Scale, and the Nurse Managers′ Empowering Behavioral Scale. Results The participants′ score of confidence professional behavior was (191.25±18.69).Age, professional title, years of working experience, hospital magnetic element, and the head nurses′ empowerment behavior were the main influencing factors of confidence professional behavior in PICC specialized nurses (all P＜0.05), which explained 68.4% of the total variation. Conclusion The confidence professional behavior of PICC specialized nurses is good, and it is influenced by va-rious factors.It is suggested to systematically establish a magnetic management system for PICC specialized nurses, grant them more empowerment and enabling behavior, in order to enhance the confidence professional behavior level of PICC specialized nurses.