Objective To evaluate the effectiveness of a teaching reform implemented in the Rehabilitation Nursing course for undergraduate nursing students.Methods A total of 114 undergraduate nursing students were divided by class into a control group (n=56) and an observation group (n=58). The control group received traditional lecture-based teaching, while the observation group underwent a reformed approach incorporating the flipped classroom model, integration of interdisciplinary content, and the creation of comprehensive hands-on scenarios. Comprehensive written examination scores, hands-on skills, self-directed learning ability, and teaching satisfaction were compared between the two groups. Results The observation group showed significantly higher scores in comprehensive written examination, hands-on skills, self-directed learning ability, and teaching satisfaction compared to the control group (all P<0.05). Conclusion The teaching reform in the Rehabilitation Nursing course is effective in enhancing undergraduate nursing students′ theoretical knowledge, hands-on skills, self-directed learning ability, and overall satisfaction with the teaching.