Objective To systematically analyze public concerns and sentiment regarding nurse-led Traditional Chinese Medicine (TCM) clinic, aiming to provide evidence for optimizing service models and informing policy development. Methods We collected relevant comments regarding nurse-led TCM clinic on Weibo, Douyin, WeChat Official Accounts, and Red Note from December 1, 2021, to December 1, 2024. A word cloud was generated to visualize high-frequency terms. Sentiment analysis of comments was performed using the SnowNLP module, and potential themes within the comments were extracted using the Latent Dirichlet Allocation (LDA) technique. Results A total of 3,459 valid comments related to nurse-led TCM clinic were collected. The median sentiment score (with interquartile range) of public comments toward nurse-led TCM clinic was 0.72 (0.36, 0.94). Four key public concerns were identified:service model, service quality, service content, and qualifications of nurses running the nurse-led TCM clinic. Conclusion The public holds a mildly positive attitude towards nurse-led TCM clinic, with notable concerns regarding the qualification, certification, and prescription rights of the nurses. It is recommended to refine relevant laws and regulations and ensure the professionalism and standardization of the nurses through measures such as specialized training and certification, thereby improving the overall quality of nurse-led TCM clinic.