Objective To develop and implement a perioperative pain management program using Intervention Mapping (IM) for alcohol-dependent patients undergoing minimally invasive lung cancer surgery and to achieve adequate pain relief and better recovery. Methods A prospective quasi-experimental study was conducted. A total of 105 alcohol-dependent patients scheduled for elective minimally invasive lung cancer surgery between January and December 2023 were assigned to the control group and received conventional perioperative pain management. Another 103 patients admitted between January and December 2024 were assigned to the intervention group and received the IM-based perioperative pain management program. Results A total of 100 patients in the control group and 101 in the intervention group completed the study. The incidence of moderate-to-severe postoperative pain was 58.00% in the control group, compared to 31.68% in the intervention group (P<0.05). The pain management satisfaction score was 6.05±1.18 in the control group, significantly lower than the 8.30±0.57 in the intervention group (P<0.05). The time to first ambulation after surgery was significantly earlier, and the rate of alcohol relapse after discharge was significantly lower in the intervention group compared to the control group (both P<0.05). Conclusion Using IM to design and implement perioperative pain management intervention can improve pain management outcomes, promote early ambulation, and enhance the quality of postoperative recovery in alcohol-dependent patients undergoing minimally invasive lung cancer surgery.