Objective To explore the effectiveness of combined Chinese herbal bath and Exercise for Cancer Patients (EXCAP) intervention on chemotherapy-induced peripheral neuropathy (CIPN) and quality of life (QoL) in patients with gastrointestinal cancer.Methods A total of 132 gastrointestinal cancer patients with CIPN after oxaliplatin-based chemotherapy were randomly assigned to one of four groups (n=33 per group):the control group (receiving routine care), the Chinese herbal bath group, the EXCAP group, and the combination group (receiving both Chinese herbal bath and EXCAP intervention). Neurotoxicity and QoL were assessed using the Functional Assessment of Cancer Therapy/Gynecologic Oncology Group-Neurotoxicity questionnaire and the European Organization for Research and Treatment of Cancer QLQ-CIPN 20 at baseline, after 3 cycles, and after 6 cycles of chemotherapy, respectively.Results Finally, 127 patients completed the study. After 3 and 6 cycles of chemotherapy, significant diffe-rences were observed in neurotoxicity and QoL scores among the four groups (both P<0.05). Pairwise comparisons revealed that the control group had significantly worse neurotoxicity and QoL scores than the other three groups, while the combination group demonstrated significantly better outcomes than all other groups.Conclusion The combination of Chinese herbal bath and EXCAP intervention can effectively mitigate neurotoxicity and improve QoL in gastrointestinal cancer patients undergoing chemotherapy.