颈椎前路手术患者吞咽困难风险预测模型的构建及验证
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女,本科,副主任护师,总护士长

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山西白求恩医院科研课题院级项目(2021YH06)


Development and validation of a risk prediction model for dysphagia after anterior cervical spine surgery
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    摘要:

    目的 构建并验证颈椎前路手术吞咽困难风险预测模型,为早期识别并预防颈椎前路手术患者吞咽困难发生提供参考。方法 采用便利抽样法,选取2023年1-12月收治的371例颈椎前路手术患者作为建模组,选取2024年1-5月收治的颈椎前路手术111例患者作为验证组。基于LASSO回归方法筛选出颈椎前路手术患者发生吞咽困难的相关危险因素,然后使用R语言构建风险预测模型和列线图模型,通过受试者特征曲线(ROC)下面积(AUC)和Hosmer-Lemeshow拟合优度检验验证模型的预测效能。结果 371例患者中发生吞咽困难107例,发生率为28.84%。多因素logistic回归分析结果显示,女性、年龄≥60岁、病程>8个月、上节段手术、内固定物为Zephir钛板及Atlantis 钛板、 颈前软组织厚度>10 mm、C2-7角度变化>5°为患者发生吞咽困难的独立危险因素(均P<0.05),围术期吞咽训练为保护性因素(P<0.05)。构建的预测模型在建模组和验证组中均P>0.05,受试者工作特征曲线下面积分别为0.830和0.825。结论 构建的风险预测模型可预测颈椎前路手术患者吞咽困难风险,可为医护人员早期制订干预措施提供参考。

    Abstract:

    Objective To develop and validate a risk prediction model for postoperative dysphagia in patients undergoing anterior cervical spine surgery to facilitate early identification and prevention.Methods A convenience sample of 371 patients who underwent anterior cervical spine surgery from January to December 2023 was used as the modeling cohort, and 111 patients who underwent the procedure from January to May 2024 as the validation cohort.Potential predictors of postoperative dysphagia were screened using LASSO regression.A risk prediction model and a nomogram were constructed in R language.Model performance was assessed by the area under the receiver operating characteristic curve (AUC) and model calibration assessed by using the Hosmer-Lemeshow goodness of fit test.Results Among the 371 patients in the modeling cohort, 107 developed dysphagia (incidence 28.84%).Multivariable logistic regression identified female sex, age ≥60 years, disease duration >8 months, upper level surgical segments, use of Zephir or Atlantis titanium fixation devices, anterior cervical soft tissue thickness >10 mm, and C2-7 angle change >5° as independent risk factors for postoperative dysphagia (all P<0.05).Perioperative swallowing training was a protective factor (P<0.05).The prediction model demonstrated good discrimination and calibration in both the modeling and validation cohorts:Hosmer-Lemeshow tests indicated acceptable fit (both P>0.05), AUCs were 0.830 and 0.825, respectively.Conclusion The risk prediction model can predict the risk of dysphagia in patients undergoing anterior cervical spine surgery, which can provide a reference for healthcare professionals to develop early and targeted interventions.

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史淑芳,郭明霞,王晶晶,薛晓玉,张霞.颈椎前路手术患者吞咽困难风险预测模型的构建及验证[J].护理学杂志,2025,(23):25-29+34

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  • 收稿日期:2025-07-19
  • 最后修改日期:2025-09-08
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  • 在线发布日期: 2026-01-14