Objective To apply the best evidence of postoperative delirium management for kidney transplant patients into clinical practice and to evaluate its effectiveness. Methods A total of 51 kidney transplant patients admitted in April to June 2024 were served as the control group receiving conventional perioperative care, while 55 patients sampled between July and September 2024 were treated as the intervention group receiving evidence-based care for postoperative delirium management.The incidence of delirium and subsyndromal delirium were compared between the two groups. Results The incidence of postoperative delirium and subsyndromal delirium were 23.53% and 37.25% in the control group, significantly higher than those in the intervention group (9.09% and 16.36%,both P＜0.05）. Conclusion Evidence-based practices empower nurses to deliver scientific, stan-dardized, and high-quality care, resulting in reducing the incidence of postoperative delirium and subsyndromal delirium in kidney transplant patients.