Objective To systematically summarize the practice content and application effects of patient navigation in Enhanced Recovery After Surgery （ERAS）.Methods A computer search of PubMed, Web of Science, Embase, Cochrane Library, CINAHL, CNKI, China National Knowledge Infrastructure, Wanfang Data, and VIP Database was conducted for relevant literature.Inclusion and exclusion criteria were used to screen and extract information from the literature. The search period was from the establishment of the database to November 22, 2024.Results A total of 17 articles were included.Navigators in ERAS were mainly nurses, who were responsible for coordinating multidisciplinary teams, patient education, full-process support, personnel training, and data collection. The implementation phase could be divided into three stages:pre-admission, during hospitalization, and post-discharge, with evaluation indicators including enhanced recovery indicators, patient and doctor evaluations, and health economic effects.Conclusion Patient navigation has shown good application effects in ERAS, promoting further development of ERAS, improving patient medical experience, and meeting patients′ personalized care needs.In the future, it is necessary to draw on international experience, build a localized navigator training system, build an information management platform to achieve cross-institutional full-process management, and extend the follow-up time to further explore the long-term application effects of the patient navigation model.