Objective To develop and verify the effectiveness of a prevention and management plan for early postoperative intolerance to enteral nutrition in esophageal cancer patients based on evidence.Methods A prevention and management plan for early postope-rative intolerance to enteral nutrition in esophageal cancer patients was developed based on evidence, and review indicators were established and clinically reviewed.The Ottawa Model of Research Use was used to analyze the barriers to evidence-based practice from three dimensions:evidence-based change, potential adopters, and practice environment, and then countermeasures were formulated.Results After the application of evidence, the department established regulations and standards for the prevention and management of early postoperative intolerance to enteral nutrition in esophageal cancer patients; except for review indicators 9 and 11, which were 100% before and after the application of evidence, the other review indicators were improved compared to before the application of evidence, among which review indicators 1, 2, 5, 6, 7, 8, and 12 were significantly improved (all P＜0.05); the scores of nurses′ knowledge on the prevention and management of early postoperative intolerance to enteral nutrition in esophageal cancer patients were significantly improved (P＜0.05); the incidence of patient feeding intolerance decreased significantly from 55.56% to 14.81%, and the time to the first anal exhaust and defecation after surgery was significantly shortened compared to before the application of evidence (all P＜0.05).Conclusion The prevention and management plan for early postoperative intole-rance to enteral nutrition in esophageal cancer patients developed based on evidence can standardize the management of early postoperative intolerance to enteral nutrition in esophageal cancer patients, improve the knowledge level of nurses, reduce the incidence of feeding intolerance, and promote patient recovery.