Objective To design and compile an evidence-based popular science manual for perinatal depression prevention, aiming to improve awareness of perinatal depression among pregnant women,families,and related practitioners,as well as to provide refe-rence for reducing the perinatal depression incidence.Methods After clarifying the theme of the popular science manual through li-terature review and combining social needs, a popular science manual writing team was established.The best evidence was summarized from top to bottom through the "6S" evidence pyramid model, and a popular science content system was constructed.The evidence summary items were transformed, and the popular science manual was written following the principles of popular science creation.After two rounds of external expert review, the manual was promoted, and satisfaction was statistically analyzed, and opinions and suggestions were collected.Results The final perinatal depression prevention popular science manual includes 4 chapters:basic knowledge, identification, screening, and scientific prevention measures and 13 sections.After distributing the manual and conducting a questionnaire survey, the mean overall satisfaction scores were:pregnant women （4.43±0.78）, family members （4.41±0.76）, medical staff （4.31±0.90）, and community workers （4.45±0.82）.Conclusion The perinatal depression prevention popular science manual is mainly guided by the needs of pregnant women, based on evidence, scientifically developed, syste-matically reliable.It has good practicality and scientific nature, taking into account humanistic care, and has been recognized by patients and the public.