Objective To understand the real work experience of full-time night shift nurses and provide references for the development and adjustment of the full-time night shift model.Methods Purposeful sampling combined with snowball sampling was used to conduct semi-structured in-depth interviews with 11 full-time night shift nurses from September to December 2024.The Framework Method was used for data analysis, and Atlas.ti 9 was used to organize the data.Results The work experience of full-time night shift nurses was refined into three themes, including multi-polar triggering factors, complex feelings and profound impact, self-regulation, and multi-party support.Conclusion Nursing managers should pay attention to the work feelings and urgent expectations of clinical nurses under the full-time night shift model, further improve policy support, optimize management models, strictly control entry standards and pre-job training, encourage and care for nurses, to improve their work enthusiasm and nursing service quality.