Objective To explore the application effect of the inpatient drug information-based transportation system, and to provide a reference for improving the efficiency and management quality of inpatient medication transfer.Methods The information-base transportation system for medications was applied in the inpatient central pharmacy, and the medication transfer efficiency and medication transfer risk events under the traditional medication transfer management model (July to December 2022, traditional group) and the information-based transportation system management model (July to December 2023, information group) were compared.Results The traditional group completed 8,635 medication transfers, and the information group completed 8,203.The medication transfer efficiency of the information group was significantly better than that of the traditional group, and the incidence of sending to the wrong department in medication transfer risk events was significantly lower than that of the traditional group (both P＜0.05).Conclusion The information-based transportation system for inpatient drugs in the Support Center has been well applied in the full-process information-based management of the Support Center. It has realized the informatization of drug transportation, improved the transportation efficiency of in-hospital drugs, and reduced transportation risk incidents.