Objective To evaluate the efficacy of Wuzisan wax therapy on the three yang meridians of the hand combined with acupoint massage in post-stroke shoulder-hand syndrome (SHS) patients, to provide reference for developing intervention protocols for this population. Methods From January to December 2023, 159 post-stroke SHS patients were randomly allocated into three groups with 53 cases each. The control group received routine rehabilitation; the wax therapy group underwent additional Wuzisan wax therapy along the three yang meridians of the hand; the combination group received wax therapy plus acupoint massage on three yang meridians of the hand. All interventions lasted 4 weeks. The overall clinical efficacy after intervention, as well as the pain scores of the affected limbs, the impairment severity, upper limb motor function, shoulder flexion range of motion (ROM), and quality of life (QoL) before the intervention, 4 weeks after the intervention, and 4 weeks after discharge were compared among the three groups. Results A total of 52 cases completed the study in each of the three groups. In terms of clinical efficacy, 4 weeks after the intervention, the clinical effectiveness rate was 84.62% in the combined therapy group, 80.77% in the wax therapy group, and 71.15% in the control group.After 4 weeks of the intervention and 4 weeks after the discharge, the scores for pain in the affected limb, impairment severity, upper limb motor function, shoulder flexion ROM, and QoL in the combination group were significantly better than those in the wax therapy group and the control group (all P<0.05). Conclusion Wuzisan wax therapy combined with acupoint massage on the three yang meridians of the hand can safely and effectively alleviate joint pain and the impairment severity in post-stroke SHS patients, improve upper limb motor function and ROM, and is conducive to the recovery of upper limb function and the improvement of quality of life in stroke patients.