Objective To systematically retrieve, evaluate, and summarize the best evidence for managing pancreatic exocrineinsufficiency (PEI) diarrhea in patients after pancreatectomy, to provide a basis for developing clinical interventions for the management of PEI diarrhea in postoperative patients with pancreatic tumors in clinical practice. Methods According to the "6S" model system, the literature related to the management of PEI diarrhea in patients after pancreatectomy was retrieved from relevant databases and websites at home and abroad. The retrieval period was from establishing the databases until March 31, 2025. The literature was screened and a quality evaluation was conducted, followed by evidence extraction, summarization, and compilation. Results A total of 11 articles wereincluded, comprising 1 clinical decision-making article, 3 guidelines, 1 systematic review, and 6 expert consensus documents. We summarized 23 pieces of evidence across four key aspects, namely screening and evaluation, drug management, nutrition management, and follow-up management. Conclusion This study outlines the best evidence for managing PEI diarrhea in patients after pancreatectomy. Healthcare professionals can develop individualized intervention plans by applying this evidence within specific clinical contexts and fully incorporating patient preferences.