Objective To explorethe effectiveness of a sequential multisensoryoral feeding training program for preterm infants, and to provide are ference for improving oral feeding outcomes. Methods A total of 138 pretermin fantsin NICU were conveniently selected and divided into two groups of 69 case seach according to the time periodthey were hospitalized. Thecontrol groupreceived the routine feeding management, and the observation group was subjected to asequential multisensoryoral feeding training program on the basis of the control group. Results There were 66 cases in the control group and 64 cases in the observation group completed the study. The scores of oral feeding readiness and neurobehavior between the two groups were significantly higher in the time, group, and interaction effects (all P<0.05); the incidence of poorfeeding and feeding delay in the observation group was significantly lower than those in the control group,and the transition time for oralfeeding of the observation group was shorter than that inthe control group (all P<0.05). Conclusion A sequential multisensory oral feeding training program can enhance oral feeding readiness, promote neuro behavioral development, improveoral feeding outcomes and shorten oral feeding process of preterminfants.