Objective To explore the family management characteristics of intergenerational caregiving for children with chronic di-seases and its key influencing factors, so as to provide a reference for developing targeted intervention measures.Methods A total of 202 grandparent caregivers of children with chronic diseases were conveniently selected from pediatric departments of two tertiary hospitals in Shenzhen, then they were investigated by using a general information questionnaire, Chinese version of the Family Management Measure, the Patient Health Questionnaire-4, the Perceived Stress Scale, and the Family APGAR Index. Latent profile analysis was conducted to explore the potential categories of family management characteristics in intergenerational caregiving for children with chronic diseases, and univariate analysis and logistic regression analysis were performed to identify the factors influencing different categories.Results The family management characteristics of intergenerational caregiving for children with chronic diseases were classified into two categories: low-efficiency family management （69.8%） and proactive family management （30.2%）.Logistic regression results indicated that, average annual medical expenses, grandparent emotional status, and perceived stress were significant influencing factors of the latent categories of family management characteristics （all P＜0.05）.Conclusion There is heterogeneity in the family management characteristics of intergenerational caregiving for children with chronic diseases. Healthcare professionals should implement targeted interventions based on the characteristics and influencing factors of family management to enhance the disease management capabilities of grandparents and improve overall family management levels.