Objective To explore the effect of specialist nurse-led "Internet plus" multidisciplinary weight management on body weight indicators and glucose and lipid metabolism indicators in type 2 diabetes patients with obesity.Methods Eighty-one type 2 diabetes patients with obesity in outpatient department from January to December 2024 were selected as the research subjects, and they received specialist nurse-led "Internet plus" multidisciplinary weight management, which included establishing a multidisciplinary weight management team, nutritional therapy, physical exercise, pharmacological treatment, lifestyle interventions, etc., and the participants were followed up and managed by specialist nurses via an Internet platform for six-month.The weight, BMI, waist circumference, glucose and lipid metabolism indicators of the participants before and after the intervention were compared.Results Seventy-five patients completed the follow-up. After 6 months of intervention, patients′ body weight, BMI and waist cir-cumference were significantly lower than those before the intervention （all P＜0.05）.Sixty-nine patients （92.0%） achieved clinically meaningful weight loss goals. After 6 months of intervention, patients′ fasting blood glucose, HbA1c, TC, TG, and LDL were significantly lower than those before the intervention （all P＜0.05）, while there was no significant difference in HDL before and after the intervention （P＞0.05）.Conclusion Implementing specialist nurse-led "Internet plus" multidisciplinary weight ma-nagement in type 2 diabetes patients with obesity can effectively control their body weight, and improve glucose and lipid metabolism.