Objective To systematically integrate the care experiences in family caregivers of patients with osteogenesis imperfecta, so as to provide a reference for developing interventions to help family caregivers actively cope with the dynamic development of the disease.Methods Systematic searches were conducted in PubMed, Embase, Web of Science, CINAHL, Cochrane Library, Scopus, Pro Quest, Ovid, China National Knowledge Infrastructure （CNKI）, Wanfang Database, VIP Database, and China Biomedical Literature Database, from the establishment of the databases to February 2025, to collect all qualitative studies on the care expe-riences in family caregivers of patients with osteogenesis imperfecta.The quality of the literature was evaluated according to the Quality Evaluation Criteria for Qualitative Research of the JBI Evidence-Based Health Care Center （2016）, and the Meta-integration was conducted by two researchers using the thematic synthesis method.Results A total of 10 studies were included, and 46 research results were refined, which were classified into 8 categories and integrated into 4 dimensions according to the dual ABCX model:cumulative multidimensional stress from initial diagnosis shock to long-term caregiving burnout （stressors resulted from the diagnosis of osteogenesis imperfecta, the "snowball effect" in long-term care）, synergistic mobilization of endogenous family resources and exogenous social capital （assistance from internal family resources, empowerment from external family resources）, cognitive restructuring from maladaptive attributions to adaptive reframing （negative cognition, positive reconstruction）, and divergent adaptation outcomes of chronic crisis versus positive adjustment （continuous crisis, benign adaptation）.Conclusion The caregiving experiences among family caregivers of patients with osteogenesis imperfecta in the entire course of the disease is dynamic and complex.Medical staff should develop stress management strategies, integrate internal and external resources, strengthen cognitive restructuring interventions, promote positive acceptance and adaptation to the disease, and enhance the caregiving experience of the caregivers.