Objective To understand the current status of quality of life and its influencing factors in patients with chronic leg wounds accompanied by edema, so as to provide a reference for developing personalized intervention strategies.Methods From November 2023 to June 2024, 214 patients with chronic leg wounds accompanied by edema admitted to four tertiary hospitals were selected by convenience sampling, then they were investigated by using a general information questionnaire, the Questionnaire on Quality of Life with Chronic Wounds (Wound-QoL), and the Well-Being in Wounds Inventory (WOWI).Results The participants′ total score of the Wound-QoL was (59.07±9.57) points, its total score and each subscale scores were negatively correlated with WOWI score (all P＜ 0.05).Multiple linear regression analysis showed that, age, occupational status, comorbid diabetes mellitus, PUSH score, degree of edema, and WOWI were the major influencing factors of quality of life in patients with chronic leg wounds accompanied by edema (all P＜0.05).Conclusion The quality of life in patients with chronic leg wounds accompanied by edema is extremely poor.Medical staff should pay attention to the elderly population and patients′ socioeconomic status, adopt a multidisciplinary management approach to strengthen the assessment and management of comorbidities, wounds, and edema. Personalized interventions and decongestion strategies should be developed to promote wound healing, and patients′ mental state should be paid attention, social support and psychological interventions should be provided to enhance their quality of life.