This paper reviews the assessment tools, current status and management of symptom clusters in Systemic Lupus Erythematosus (SLE) patients. Assessment tools includes the SLE Symptom Checklist, the Systemic Lupus Activity Questionnaire and the Brief Index of Lupus Damage, SLE symptom clusters contains fatigue-related symptom cluster, itch-pain related symptom cluster, skin change related symptom cluster, and weight-related symptom cluster, and management involves exercise combined with nutrition intervention, Chinese medicine therapy, personalized health education and nursing care intervention,continuous care intervention and remote nursing intervention. This paper aims to provide references for research on symptom clusters and clinical symptom management in SLE patients.