Objective To systematically analyze the relevant research on the experiences of patients with knee osteoarthritis using mobile applications for exercise rehabilitation, aiming to provide references for the clinical application and adaptation of mobile applications for patients with knee osteoarthritis. Methods A systematic search was conducted across major domestic and international databases for relevant qualitative studies,the retrieval period was from the database inception to February 23, 2025.Literature quality was evaluated using the Australian JBI Centre for Evidence-Based Health Care Quality Assessment Criteria for Qualitative Research (2016 edition),and findings were synthesized using a meta-aggregation approach. Results A total of 9 articles were included, yielding 39 findings,which were categorized into 10 themes,ultimately forming 3 integrated results:the perceived benefits of using mobile apps for exercise rehabilitation, the barriers and challenges during exercise rehabilitation with mobile apps, and the needs and visions for the optimization of mobile application functions. Conclusion Patients with knee osteoarthritis show a positive attitude towards the use of mobile applications. The optimization and upgrading of mobile applications should always focus on the patient experience, establish an intelligent exercise rehabilitation system to meet the individualized exercise rehabilitation needs of patients, then build a peer support platform accordingly to provide patients with emotional care support.