Objective To explore the effects of board games in the teaching of delirium knowledge for standardized training nurses, so as to provide a reference for the standardized training of nurses. Methods A multidisciplinary team was established to develop the first version of the delirium knowledge board game by using literature analysis and brain storming methods, then two rounds of Delphi expert consultation were conducted to improve its problem settings and game rules, finally the delirium knowledge board game was formed after a pilot study. Seventy nurses undergoing standardized training in the ICU were divided into an intervention group and a control group by using simple randomizaton, with 35 nurses in each group. Both groups received a 30-45 minutes delirium knowledge education lecture, while the intervention group additionally received a 20-30 minutes delirium knowledge board game after the lecture. The ICU Delirium Knowledge Questionnaire and the Nurses′ Delirium Nursing Self-Efficacy Scale were used to investigate the two groups before the intervention, immediately after the intervention, and one month after the intervention. And teaching satisfaction of the two groups were assessed one month after the intervention. Results The scores of delirium knowledge and delirium nursing self-efficacy in the intervention group immediately after the intervention and one month after the intervention were significantly higher than those in the control group, and the teaching satisfaction of the intervention group was significantly higher than that of the control group (all P<0.05). Conclusion The use of board games as an aid in the teaching of delirium knowledge among standardized training nurses is conducive to improving their delirium knowledge and self-efficacy in delirium care, thereby enhancing nurses′ satisfaction with the teaching methods.