Objective To analyze the current research status and hot topics of nursing in Chimeric Antigen Receptor T (CAR-T) cell therapy, so as to provide a reference for futher exploration in this field. Methods Citespace 6.3.R1 software was used to visualize and analyze the relevant literature related to the nursing of CAR-T cell therapy published in Chinese National Knowledge Infrastructure (CNKI), Wanfang Data Knowledge Service Platform, VIP Database and Web of Science Core Collection from the date of establishment of the database to October 1, 2024. Results A total of 256 Chinese articles and 268 English articles were retrieved, and the number of published articles showed an overall upward trend. The nursing-related hot topics of CAR-T cell therapy, both domestically and internationally, included economic evaluation, symptom management, quality of life, and transitional care, etc. Conclusion The nursing in CAR-T cell therapy develops rapidly in recent years. Future directions should focus on comprehensive economic assessments, multidisciplinary collaboration, standardized holistic nursing management, and the establishment of long-term follow-up mechanisms, etc. .