Objective To investigate the current status and influencing factors of perceived spousal responses to pain in multiple myeloma patients with bone pain, so as to provide references for developing targeted intervention strategies. Methods A total of 245 multiple myeloma patients with bone pain were selected conveniently, then they were investigated by using a general information questionnaire, the Scale of Pain-Relevant Responses from Spouse for Chronic Pain Patients, the Hospital Anxiety and Depression Scale, the Visual Analogue Scale and the Barthel index. Results The participants′ score of perceived spousal responses to pain was (91.64±12.96) points. Multivariate linear regression analysis indicated that, gender, residential status, anxiety, pain intensity, and self-care ability were the major influencing factors of perceived spousal responses to pain in multiple myeloma patients with bone pain (all P<0.05), explaining 22.1% of the total variance. Conclusion Perceived spousal responses to pain are at high levels among multiple myeloma patients with bone pain and are affected by various influencing factors. Medical staff should provide tailored pain management training to patients and spouses to improve ignorant pain cognition and behaviors.