Objective To explore the effects of Satir model empowerment on emergency patients with suicide attempts after deliberate self-poisoning and their family caregivers. Methods Eighty-eight pairs of emergency patients with suicide attempts after deliberate self-poisoning and their family caregivers were randomized into a control group or and an intervention group, with 44 pairs in each group. The control group received routine nursing care, while the intervention group additionally received Satir model empowerment intervention, focusing on family system repair. Results At discharge, 43 pairs in each group completed the study. At 90 days after discharge, 32 pairs in the control group and 31 pairs in the intervention group completed the follow-up. At both discharge and the 90-day follow-up, the family caregivers′ scores of negative beliefs about rumination in the intervention group were significantly lower than those of the control group, and their scores of self-forgiveness, post-traumatic growth, and family resilience were significantly higher than those of the caregivers in the control group (all P<0.05). The incidence of repeat suicide behaviors within 3 months post-discharge was significantly lower in the intervention group than that in the control group (P<0.05). Conclusion Empowering family caregivers using the Satir model effectively improves their psychological state and family resilience, thereby reducing the risk of repeat suicide behaviors after discharge in emergency patients with suicide attempts after deliberate self-poisoning.