Objective To construct and apply a non-weight-bearing exercise management program for patients undergoing diabetic foot ulcer surgery, and to improve patient outcomes.Methods A total of 90 patients to receive diabetic foot ulcer surgery were divided into 2 groups, with 45 cases in each group.The control group received routine nursing, local wound treatment and follow-up management.On this basis, the intervention group was subjected to a postoperative non-weight-bearing exercise management program for diabetic foot ulcers, developed based on the best available evidence.Results After 4 weeks of intervention, the fasting blood glucose level in the intervention group was significantly lower than that of the control group, while the ankle-brachial index, self-management ability, and activities of daily living were significantly higher than those in the control group (all P＜0.05).The incidence of postoperative adverse events in the intervention group was lower than that in the control group, but the difference between the two groups was not statistically significant (all P＞0.05).Conclusion The non-weight-bearing exercise management program developed based on the best evidence for patients undergoing diabetic foot ulcer surgery can improve local blood circulation in the lower limbs, reduce blood glucose levels, and enhance patients′ self-management skills and activities of daily living.