Objective To know the current situation of toxic leadership behavior of nurse managers perceived by nurses and its inf-luence on nurses′ career compromise, and to explore the mediating effect of organizational silence of nurses on toxic leadership behaviors of nurse managers and career compromise, so as to provide references for hospital administrators to formulate policies to stabilize nursing team.Methods A total of 512 nurses from a tertiary hospital in China were investigated by the general data questionnaire, the Toxic Leadership Behaviors of Nurse Managers Scale, the Organizational Silence Scale and the Career Compromise Scale.Results The score of toxic leadership behavior of nursing managers were 68.18±24.57, the score of organizational silence were 26.03±9.53 and the score of career compromise were 29.51±9.09. Organizational silence had a mediating effect between toxic leadership behavior of nursing managers and career compromise of nurses, and the mediating effect accounted for 42.05%. Conclusion Toxic leadership behaviors of nurse managers could directly influence nurses′ career compromise behavior, and influence nurses′ career compromise through the mediation of organizational silence.It is suggested that hospital managers should pay attention to and formulate relevant policies to eliminate the emergence of toxic leadership behaviors in the organization and reduce or avoid the phenomenon of nurse organization silence in order to achieve the stability and development of the nursing team.