Objective To describe the level and influencing factors of thriving at work among psychiatric nurses, and to provide reference for improving their thriving at work. Methods A convenience sample of 824 psychiatric nurses were selected from 9 psychiatric hospitals in Henan Province in August and September 2024 and were invited to administer a battery of questionnaires, including a general information questionnaire, the Thriving at Work Scale, the Job Crafting Scale, the Work-Family Enrichment Scale, and the Essentials of Magnetism Scale.Results The total score of thriving at work was (29.44±5.95). Multiple linear regression showed that gender, job crafting, work-family enrichment and hospital Magnet status were the factors affecting thriving at work among psychiatric nurses (all P<0.05), accounting for 58.7% of the total variance. Conclusion Thriving at work among psychiatric nurses is at a moderate level and needs further improvement. Nursing managers should take effective measures to improve psychiatric nurses′ job crafting behaviors and work-family enrichment, and promote hospital magnetism, thus to enhance thriving at work among psychiatric nurses.