Objective To evaluate the efficacy of smart gloves on handgrip exercise in elderly bedridden patients with peripherally inserted central catheters (PICC).Methods Sixty-eight bedridden elderly patients with PICC were allocated to a control group (n=34), receiving routine handgrip exercise using grip balls, or an observation group (n=34), receiving smart glove-assisted exercise. Exercise compliance, axillary vein time-averaged mean velocity (TAMV), and the incidence of PICC catheter-related thrombosis （PICC-CRT） were assessed at day 28 post- insertion to compare the efficacy between the two groups. Results Thirty-two patients in each group completed the study. Compared to controls, the observation group demonstrated significantly higher exercise compliance, increased axillary vein TAMV and lower CRT incidence at day 28 post-insertion (all P<0.05). Conclusion Smart gloves significantly improve handgrip exercise compliance, augment venous hemodynamics, and reduce CRT risk in elderly bedridden PICC patients.