Abstract:Objective To understand the current status and influencing factors of proactive innovation behavior among nurse specia-lists in Henan Province, and to provide a reference for targeted management.Methods From May to August 2024, 1,018 nurse specialists from 33 medical institutions in Henan Province were selected by convenience sampling.Surveys were conducted using a general information questionnaire, the Proactive Innovation Behavior Scale, and the Employee Sense of Gain Scale.Results The total score of proactive innovation behavior among nurse specialists was (54.46±11.53) points.The scores for the dimensions of spontaneity, preliminary preparation, and overcoming obstacles were (3.99±0.87), (4.03±0.85), and (4.06±0.84) points, respectively.Multiple linear regression showed that, professional title, position, years of work, research experience, and sense of work gain were influencing factors of proactive innovation behavior among nurse specialists (all P<0.05).Conclusion Clinical nurse specialists demonstrate a medium-to-high level of proactive innovation behavior, which is influenced by multiple factors.Nursing managers should pay attention to the development of nurse specialists′ innovation activities, focus on factors enhancing their proactive innovation ability, and actively explore innovative training models to promote proactive innovation among nurse specialists.