Abstract:Objective To apply the Knowledge-to-Action framework to conduct evidence-based practice for the perioperative management of patients with aortic dissection and to evaluate its application effects.Methods From November 2024 to February 2025, evidence for perioperative management of aortic dissection was searched and introduced into clinical settings, and an evidence-based protocol was developed and implemented.Pre- and post-implementation comparisons were made regarding nurses′ knowledge scores on perioperative management, the execution rates of various audit indicators, incidence of postoperative complications, intensive care unit (ICU) stay duration, and length of hospitalization.Results A total of 22 audit indicators were established.After implementation of evidence-based practice, nurses′ knowledge related to perioperative management evidence of aortic dissection significantly improved, and the execution rates of 15 audit indicators increased significantly (all P<0.05).Additionally, patients′ ICU stay and hospitalization time were significantly shortened (both P<0.05).Conclusion The implementation of evidence-based perioperative management strategies for patients with aortic dissection can improve nurses′ relevant knowledge and skills, stan-dardize clinical nursing behaviors, optimize patient health outcomes, and accelerate postoperative recovery.