Objective To investigate the effectiveness of multidisciplinary health management on in vitro fertilization-embryo transfer (IVF-ET) outcomes, weight loss, mental state, and self-management ability in women with polycystic ovary syndrome (PCOS). Methods A total of 330 women with PCOS were randomized into a control group and an observation group of 165. The control group received routine nursing care, while the observation group additionally received multidisciplinary health management, including body weight management, lifestyle modification, and mental health interventions. IVF-ET outcomes, waist circumference, body mass index (BMI), anxiety/depression scores, and self-management ability were compared between the two groups. Results In total, 160 cases in the control group and 164 in the observation group completed the study. After the intervention, the observation group demonstrated significantly lower BMI, waist circumference, anxiety and depression scores, whereas significantly higher fertilization rate, cleavage rate, high-quality embryo rate, clinical pregnancy rate, and self-management ability compared to the control group (all P<0.05). Conclusion Multidisciplinary health management effectively improves weight control, mental state, and self-management ability in women with PCOS, thereby enhances the success rate of IVF-ET.