Objective To establish and implement quality improvement strategies for nursing humanistic care in hospital, and to provide reference for improving the management effectiveness of humanistic care in clinical nursing. Methods Using literature review and root cause analysis, the proximal and root causes of quality defects in humanistic care in nursing were deeply analyzed. Based on the actual situation of the hospital, a series of quality improvement strategies were formulated and implemented, which included revising the management system for humanistic care and nursing, constructing a hierarchical training course for nurses on humanistic care, implementing supervision of the humanistic care process, and formulating evaluation standards for the quality of humanistic care. The patient satisfaction, nurses′ humanistic care ability, nurses′ job satisfaction, and nursing managers′ caring leadership were compared before and after the implementation of the quality improvement strategies. Results After implementing the quality improvement strategies, the scores of discharged patients′ satisfaction, nurses' humanistic care ability, nurses' job satisfaction, and nursing managers′ caring leadership were significantly higher than before (all P<0.05). Conclusion Conducting quality improvement work for nursing humanistic care in hospital can enhance nurses′ humanistic care ability, improve patient satisfaction, and help build a harmonious doctor-patient relationship.