Objective To summarize the best evidence related to fatigue management in HIV/AIDS patients, and to provide reference for clinical staffs to carry out fatigue management practice. Methods Evidence on fatigue management in HIV/AIDS patients was systematically searched in domestic and foreign databases and professional websites from database inception to August 1, 2024. Two researchers evaluated the quality of the literature and extracted relevant evidence. Results A total of 14 literatures were included, consisting of 5 guidelines, 1 evidence summary, 4 systematic reviews, and 4 randomized controlled trials. Twenty-five best practices were identified and categorized into 8 thematic domains: screening and assessment of fatigue, exercise intervention, psychosocial therapy, complementary and alternative therapy, sleep management, medication management, follow-up management, co-decision making and multidisciplinary collaboration. Conclusion Clinical staffs should pay attention to fatigue management of HIV/AIDS patients, combine with the actual clinical situation and patient preferences, implement effective and safe fatigue management programs to improve the prognosis and quality of life of patients.