Objective To develop a rehabilitation follow-up system for patients with cardiac pacemaker implantation based on "Internet+" and evaluate its application effects. Methods A research team was established to construct the rehabilitation follow-up system. A total of 96 patients were divided into a control group and an intervention group (48 cases each) according to admission time. The control group received routine care, while the intervention group was managed by the rehabilitation follow-up system. After 6 months of intervention, pacemaker-related knowledge, self-efficacy, and health-related quality of life were compared between the two groups. Results Forty-seven patients in each group completed the study. After 6 months, the intervention group showed significantly higher scores in pacemaker-related knowledge, self-efficacy, and health-related quality of life compared to the control group (all P<0.05). Conclusion The "Internet+"-based rehabilitation follow-up system for patients with cardiac pacemaker implantation can effectively improve patients′ pacemaker-related knowledge, self-efficacy, and health-related quality of life, promoting the recovery of patients after pacemaker implantation.