Objective To explore the application effect of Connect-Home transitional care intervention program in lymphoma patients undergoing chemotherapy. Methods A total of 100 malignant lymphoma patients hospitalized for the first-cycle chemotherapy from August to December 2023 were randomized into an intervention group and a control group,with 50 cases in each group. The control group received routine transitional care, while the intervention group received the Connect-Home transitional care intervention program, which involved developing a transitional care plan based on transitional care needs, providing integrated online-offline transitional care services, and making quality improvements based on patient needs and key issues during implementation. Results One week and two weeks after discharge, the transitional care quality scores of the intervention group were significantly higher than those of the control group, the time effect and group×time interaction effect of the two groups in the total quality of life score were significant (all P<0.05). Conclusion The implementation of the Connect-Home transitional care intervention program is beneficial for improving the quality of transitional care during the chemotherapy period and enhancing the quality of life of patients with lymphoma.