Objective To summarize and organize the best evidence regarding the management of limb activity on the side of Periphe-rally Inserted Central Catheterization (PICC), so as to provide references for relevant study and clinical practice. Methods Relevant domestic and international guidelines websites, professional association websites, and databases were searched for articles on limb activity management of PICC. The retrieval period was from the database inception to November 2024. Quality assessment, evidence extraction and summarization were conducted independently by 2 researchers. Results A total of 14 articles were included, among which 4 were randomized controlled studies, 3 were guidelines, 3 were expert consensus, and 4 were systematic evaluations. Seventeen evidence items were summarized and categorized into 4 evidence topics: activity assessment, functional exercise (exercise principles, timing, program, and auxiliary content), daily life (recommended and avoided activities), and home and prevention education. Conclusion The study summarized the best evidence for specific and actionable limb activity management on the side of PICC. It is recommended to pay full attention to patients′ activity attitudes and maintain activity balance in clinical practice in the future, so as to improve the quality and safety of PICC.