Objective To explore the application effect of a nurse-led hospital-community-family trinity linkage model in patients with acute myocardial infarction (AMI). Methods A discharge preparation service nurse-led hospital-community-family trinity linkage model was established after literature analysis and expert meetings, including case file establishment, medication guidance, exercise guidance, dietary guidance, smoking cessation guidance, psychological guidance, emergency care guidance, discharge preparation services guidance, and follow-up management. Then a total of 60 AMI inpatients after Percutaneous Coronary Intervention (PCI) and admitted to cardiovascular department from September 2023 and March 2024 were divided into a control group and an intervention group chronologically, with 30 cases in each group. The control group received AMI routine management after PCI, while the intervention group was managed by the discharge preparation service nurse according to the hospital-community-family trinity linkage model. Results Totally 29 patients in the control group and 28 patients in the intervention group completed the study. The scores of readiness for hospital discharge scale in the intervention group was significantly higher than that in the control group, and its scores of coronary artery disease self-management scale at one month and two months after discharge were also significantly higher than those in the control group (all P＜0.05). Conclusion Implementation of the nurse-led hospital-community-family trinity linkage model can improve the readiness for hospital discharge and self-management ability after discharge for AMI patients after PCI, and promote their recovery.