Objective To develop and evaluate the application of the CARE management model for enteral nutrition-related diarrhea （ENRD） among hospitalized patients.Methods A multidisciplinary management team was formed to develop the CARE management model for ENRD based on evidence-based practices, surveys, and multiple rounds of expert consultations.This model encompassed four dimensions: comprehensive prevention, accurate assessment, referrals and decisions, and evaluation and monitoring.A total of 1 085 adult inpatients received enteral nutrition support from May 2021 to July 2021 were selected as the control group, who were given routine nursing care measures.From November 2022, to February 2023, another 1 083 adult inpatients were seen as the experimental group and managed with the CARE management model for ENRD.The incidence of diarrhea during enteral nutrition support was compared between the two groups.Changes in the knowledge and attitude scores regarding ENRD among the nurses were also compared.Results The incidence of ENRD in the control group was 22.30%, versus 13.48% in the experimental group （P＜0.05）.The definitions and attitude scores among nurses regarding ENRD significantly improved （P＜0.05）.Conclusion Implementing the CARE management model for ENRD in adult inpatients can effectively reduce the incidence of diarrhea, and enhance nurses′ knowledge and attitude level regarding ENRD.